DNA damage checkpoint kinase CHK1 regulates DNA replication, phase transition, and mitosis, and the elevated expression of CHK1 is found to be significantly associated with prognosis, recurrence, and even therapy resistance in acute myeloid leukemia, hepatocellular carcinoma, breast carcinoma, and colorectal carcinoma (24). This evidence concerns the gene CHEK1 and hepatocellular carcinoma.