Among these identified CCC genes, the aberrant regulation of BRCA1 (51), BRSK1 (52), BUB1 (53), CCNB1 (54), CDC25C (55), CDKN1B (56), CLOCK (57), CNOT6 and CNOT6L (58), CNOT7 (59), MAD2L1 (60), ORC1 (61), PLK1 (62), SETMAR (63), and ZW10 (64) has been found to exert influences on CRC cell lines or the prognosis of colon or rectum cancer patients. Here, CLOCK is linked to rectal cancer.