With the rapid development of next-generation sequencing (NGS), comprehensive genomic profiling of CRC has revealed that genetic (KRAS, TP53, PIK3CA, and APC) and epigenetic (hypomethylated CEP55, FOXD3, FOXF2, GNAO1, GRIA4, and KCNA5) alterations potentially contribute to the colorectal carcinogenesis (6, 7). This evidence concerns the gene PIK3CA and colorectal carcinoma.