CD4 and cancer: Correspondingly, the high CCC score group had a higher level of most of the anticancer immunity cycle activities, including step 1 of cancer cell antigen release, step 3 of priming and activation, step 4 (trafficking to tumors) of CD4 T cell, dendritic cell, eosinophil, macrophage, and Th17 cell recruiting, and step 5 of infiltration of immune cells into tumors (p< 0.05, Figure 9B).