The patient was a 52-year-old woman with a detected prolactinoma with acoustic and optic hallucinations, as well as restlessness, depression, and decreased libido. The patient had been taking 400 mg/day of amisulpride for 10 months. The patient was switched to 10 mg/day of olanzapine, and prolactin decreased significantly from 185 ng/mL to 70 ng/mL. This evidence concerns the gene PRL and depressive disorder.