For example, in in-vivo and in-vitro studies, Zhang et al. have demonstrated that irisin-associated activation of sirtuin 1 (SIRT1)/nuclear factor E2-related factor 2 (Nrf2) inhibits ferroptosis to attenuate renal injury in sepsis patients (Qiongyue et al., 2022). This evidence concerns the gene SIRT1 and Sepsis.