In contrast, four patients had progressive disease (PD); two patients with glioblastoma harboring BRCA1 c.5153-1G > C and BRCA2 p.S1982fs received a PARP inhibitor (veliparib and olaparib) and had PD after 1.4 and 0.2 months, respectively. The gene discussed is BRCA1; the disease is glioblastoma.