PF4 and COVID-19: High mobility group frame 1 protein (HMGB1)+pEVs and platelet factor 4 (PF4)+pEVs may promote neutrophil activation and the formation of NETs in COVID‐19.[186, 197] Furthermore, pEVs have been shown to promote NETs generation during SARS‐CoV‐2 infection through TLR2 and CLEC5A‐dependent mechanisms.[198] In conclusion, SARS‐CoV2 infection or pro‐inflammatory mediators activated platelets, damaged endothelial cells, and immune cells, resulting in the release of large volumes of pro‐coagulant EVs.