For example, PRSS12 displayed the highest significant enrichment of pathogenic variants in cancer compared to control (Log2 OR = 3.74, FDR = 9.86 × 10−4), next to OTOG (Log2 OR = 2.68, FDR = 1.70 × 10−3), ATP7B (Log2 OR = 2.61, FDR = 2.00 × 10−3), AAGAB (Log2 OR = 3.45, P = 7.12 × 10−3), and PAX4 (Log2 OR = 1.98, FDR = 9.31 × 10−3). This evidence concerns the gene OTOG and cancer.