For example, PRSS12 in Panc-AdenoCA, ABCC11 in liver hepatocellular carcinoma (Liver-HCC), and NOD2 in skin melanomas (Skin-Melanoma) show tissue-specific expression patterns (Additional file 1: Table 7 and Additional file 2: Fig. S9c). The gene discussed is NOD2; the disease is cutaneous melanoma.