In addition to classical ligand-receptor-induced trogocytosis, such as CD80-CD28,35 and MHC-TCR,36 antibodies and CAR molecules have also been found to mediate the same effects.24,37–39 These novel findings reveal the comprehensive modulation of trogocytosis, that it can induce fratricide effect of trogocytotic T cells,40 as well as CAR-T cells,24 or reduce antigen density of tumor cells,41 all of these benefit tumor immune escape and was considered to be one of the key mechanisms in the failure of CAR-T cell therapy.42 Here, CD28 is linked to neoplasm.