Because cholesterol metabolism is a well-known factor in membrane biomechanics and protein interaction,70–72 and retrospective studies have reported the protection effect of statins against cancer,73–75 we hypothesized that inhibiting HMG-CoA reductase (the rate-limiting enzyme of the mevalonate pathway that is enriched in various kinds of malignancies)76,77 may protect CAR molecule from the undergoing transfer, thus facilitating serial killing. Here, HMGCR is linked to cancer.