Despite we were not able to confirm a similar impact of microglial TNFR2 ablation after SCI in males, which is a clear limitation of our study, these results open to the intriguing possibility that TNFR2 signaling may play a role in driving the sex-dependent differences in microglia reactivity described after stroke and other types of acute CNS injury (Banerjee and McCullough, 2022; Tariq et al., 2022; Ugidos et al., 2022). The gene discussed is TNFRSF1B; the disease is stroke disorder.