However, we do not exclude that additional mechanisms may contribute to the sex-specific effects of microglial TNFR2 ablation, including a different epigenetic regulation (i.e., DNA methylation, histone modifications, and non-coding RNAs) of TNFR2 downstream genes in males and females, as already shown for interferon-responsive genes in rodent models and human stroke cases (Qi et al., 2021; Ratnu et al., 2017). The gene discussed is TNFRSF1B; the disease is Stroke.