TNFRSF1B and neurodegenerative disease: Hence, we propose that TNFR2 levels in the CSF may represent a useful biomarker reflecting the inflammatory processes taking place in IS and SCI patients, as already proposed in the context of other neurodegenerative diseases (Jiang et al., 2011; Magliozzi et al., 2021; Pillai et al., 2021).