Based on the distinct structural features and cellular expression profiles, several experimental studies have highlighted the opposite role of TNFRs in neurological diseases, with TNFR1 mediating dominantly the pro-inflammatory activities of TNF, and TNFR2 being primarily involved in neuroprotective and neuroreparative processes through tmTNF binding (Brambilla et al., 2011; Probert, 2015). This evidence concerns the gene TNF and nervous system disorder.