In considering the normal-11p15 nonBWS-WT samples from Murphy et al., there was a clear separation of control kidney and BWS non-tumor kidney samples in the first principal component (Dim1), while the WT samples separated along the second principal component (Dim2) according to their methylation status at 11p15 (normal vs altered) (Fig. 2D). The gene discussed is TXNL4B; the disease is neoplasm.