Youth with TPD had higher IL-6 (Hedge’s g = 0.35, 95%CI0.11 – 0.64,k = 4,N = 258,I2 = 0%) compared to youth without psychosis in the meta-analysis (Chen et al., 2021; Gariup et al., 2015; Li et al., 2022; Simsek et al., 2016b). The gene discussed is IL6; the disease is psychotic disorder.