Additionally, many promising immune and oxidative stress markers of psychosis identified in the adult literature, including elevated homocysteine, nucleic acid oxidative stress markers, IL-1β, soluble IL-2 receptor (sIL2-r), and monocytes, and lower total antioxidant status and omega-3 fatty acids were understudied or altogether lacking in pediatric threshold and subthreshold psychosis (Fraguas et al., 2019; Jorgensen et al., 2022; Upthegrove et al., 2014). The gene discussed is IL1B; the disease is psychotic disorder.