IL6 and psychotic disorder: Specifically, the largest subthreshold psychosis study to investigate IL-6 is part of the Avon Longitudinal Study of Parents and Children (ALSPAC), which found serum IL-6 at age 9 was associated with PLEs at age 18 (Khandaker et al., 2014a) but not age 13 (Khandaker et al., 2014b) after adjusting for many sociodemographic factors.