The meta-analyses found that youth with threshold psychotic disorders had higher neutrophil/lymphocyte ratio (Hedge’s g = 0.40, 95 % CI 0.17 – 0.64) tumor necrosis factor (Hedge’s g = 0.38, 95 % CI 0.06 – 0.69), C-reactive protein (Hedge’s g = 0.38, 95 % CI 0.05 – 0.70), interleukin-6 (Hedge’s g = 0.35; 95 % CI 0.11 – 0.64), and total white blood cell count (Hedge’s g = 0.29 95 % CI 0.12 – 0.46) compared to youth without psychosis. The gene discussed is CRP; the disease is psychotic disorder.