Evidence shows that dysfunction of insulin receptor downstream PI3K/AKT signaling pathway leads to the development of obesity and type-2 diabetes mellitus because AKT activation promotes glucose transporter 4 (GLUT4) translocation from cytosol to the cell membrane and uptake of excess glucose in the bloodstream (14, 15, 16). The gene discussed is AKT1; the disease is obesity due to melanocortin 4 receptor deficiency.