In addition, IL-12 is known to increase the antitumor activity of natural killer (NK) cells, and its activity is antagonized primarily by IL-10, with its immunosuppressive or immunostimulatory action.26, 27, 28The present study showed that these cytokines not only played an important role in ovarian cancer, but that they also interacted in the process.. Here, IL10 is linked to ovarian carcinoma.