In the study by Underhill et al. (which is a retrospective case control study), PPROM risk was tried to be predicted by the serum biglycan and decorin levels in 15 to 20 weeks of pregnancy.38They found an AUC value of 0.659 for biglycan and 0.563 for decorin. This evidence concerns the gene BGN and preterm premature rupture of the membranes.