Previous studies reported that the ABC transporter G family (ABCG1/5/8) functioned by facilitating cholesterol transport from the endoplasmic reticulum to the plasma membrane [41, 42, 43], and our recent study also revealed that USP24 stabilized ABCG2 to enhance the efflux of Taxol from cancer cells, resulting in drug resistance during cancer therapy [14]. This evidence concerns the gene ABCG1 and cancer.