Table 1 details their clinical and biological characteristics. Most patients fit the typical profile of septic individuals, being older males with high severity scores. Generally, these patients displayed reduced mHLA-DR expression and a tendency toward CD4+ T cell lymphopenia, indicative of the immunosuppressed state commonly observed in sepsis. Information pertaining to different etiologies and details about healthy donors are presented in the Supplementary Table S1. The gene discussed is CD4; the disease is Sepsis.