Prior studies have linked WM disease to both HIV disease-related factors (e.g., lower CD4+ T-cell nadir, longer duration of HIV infection, as well as CD4+ T-cell recovery) and comorbidities (e.g., hepatitis C virus (HCV) seropositivity, diabetes, and cerebrovascular risk factors) [4,23,24,26,27]. The gene discussed is CD4; the disease is HIV infectious disease.