According to the European Late Presenter Consensus Working Group, late presentation for HIV care refers to individuals presenting for care with a CD4 count below 350 cells/μL, or with an AIDS-defining event regardless of the CD4 cell count, while very late presenters (VLP) are characterized by presenting a CD4 count lower than 200 cells/μL or an AIDS-defining event, regardless of the CD4 cell count [48]. The gene discussed is CD4; the disease is AIDS.