CSF1R and encephalomyelitis: Several techniques have been used to parse out the roles of microglia versus macrophages in MHV encephalomyelitis, including Ccr2−/− and Ccl2−/− mice, in which monocyte recruitment is impaired, and the administration of PLX5622, an inhibitor of colony-stimulating factor 1 receptor (CSF1R) tyrosine kinase.