More specifically, T2D is accompanied by the recruitment of M1 polarized macrophages within the adipose tissue where they will secrete significant amounts of proinflammatory mediators (tumor necrosis factor α—TNF-α, C-reactive protein—CRP, interleukin-1β—IL-1β, CCL2, CCL3, CXCL8, IL-6, and IL-12) [44,45]. This evidence concerns the gene TNF and type 2 diabetes mellitus.