Instead, the Epstein–Barr virus (EBV) can reduce the expression of Keap1 through the p62-Keap1-Nrf2 pathway in nasopharyngeal carcinoma cells (NPC), resulting in an increase in Nrf2 in the nucleus and a further upregulation of GPX4 expression. This evidence concerns the gene KEAP1 and nasopharyngeal carcinoma.