However, despite major differences in myeloid and lymphoid lineage and immune function, all three types of APCs lead to HIV-1 trans-infection via a type II C-type lectin receptor DC-specific ICAM-3 grabbing non-integrin (DC-SIGN; CD209) [15], whereas monocytes/macrophages and myeloid DCs but not B lymphocytes also express the lectin Siglec-1 (CD169) that drives HIV-1 trans-infection [16,17,18,19]. Here, SIGLEC1 is linked to infection.