Each of the cell types was infected with LCMV, and the extent of infection was determined using RT-PCR at 24 h.p.i. In line with the PDIA4 and PDIA5 siRNA experiments, infection with LCMV showed a reproducible reduction in PDIA4-KO A549 cells and a slight reduction in PDIA5-KO A549 cells (Figure 3D). The gene discussed is PDIA4; the disease is infection.