Then, we measured the IFN-β and IFN-λ mRNA in the uninfected and RV-infected condition and found higher levels by trend in the control group and lower levels in the RV-infected NEC culture derived from subjects with asthma (Figure 1g,h), indicating a defect in interferon response in nasal epithelial cells derived from asthmatic subjects and especially upon RV-A1b infection in combination with higher RV-A1b load in the cells. The gene discussed is IFNB1; the disease is asthma.