ICP0 induces the degradation of cellular proteins such as PML-NBs and the centromeric repressive histone H3 variants [129,130,131,132] Other PML-NB constituent proteins include Sp100 (speckled protein of 100 kDa), hDaxx (human-death-domain-associated protein 6), and ATRX (alpha thalassemia/mental retardation syndrome X-linked), which have been demonstrated to limit the replication of ICP0-null mutants [131,133]. This evidence concerns the gene PML and alpha thalassemia spectrum.