CCND1 and intestinal polyp: Riccardin D (9) also exhibited the prevention of intestinal adenoma (polyp) formation in APCMin/+ mice, a decrease in beta-catenin and cyclin D1 expression, the prevention of proliferation of intestinal polyps, and the triggeroing of apoptosis via the caspase-dependent pathway and te decrease in angiogenesis in intestinal polyps [120].