Homocysteine levels were more remarkable among the overweight patients, with higher insulin, Peptide C, and HOMA-IR and lower QUICK index, and higher among patients with PKU vs. hyperphenylalaninemia and vs. controls, with homocysteine levels correlated with BMI, WC, and age [182,233,234]. The gene discussed is INS; the disease is Hyperphenylalaninemia.