CD4 and myeloid sarcoma: Furthermore, NLRP3 appears to act as a bridge between the innate and adaptive immune responses in the early stages of MS, promoting the migration of macrophages, dendritic cells, and myelin-specific autoreactive CD4+ T cells into the CNS and, therefore, it may be considered a critical factor in the development of neuroinflammation and an interesting therapeutic target in immune-related disorders [132].