In a system network analysis using the Kyoto encyclopedia of genes, genome functional analysis, and gene ontology using RA models, it was found that PF targeted eight genes, including IL-6, Fos, LGALS3, TNF, VEGFA, IL-1β, TP53, and STAT3, and PF down-regulated the expression of STAT3, LGALS3, and VEGFA [23]. This evidence concerns the gene STAT3 and rheumatoid arthritis.