Overall, energy restriction plus exercise has been shown to decrease weight [104,105,106], BMI [101,102,104,105], WC [101,102,104,106,107], hip circumference [104], body fat [105], fat-free mass [105], lean body mass [101,102], blood pressure [104,106], HOMA-IR [106,107], glucose [106], insulin [106], triglycerides [104], total cholesterol [101,102,106], and LDL-C concentrations [104,106], and to improve HDL-C concentrations [107] in individuals with PCOS. Here, INS is linked to polycystic ovary syndrome.