PPARA and Hepatic steatosis: Specifically, the authors found that curcumin was able to block Notch signaling in the liver of rats fed with HFD who developed hepatic steatosis, by the up-regulation of PPARα, (thus increasing FFAs oxidation), and by the down-regulation of lipogenic genes such as FAS and ACC (thus promoting lipids accumulation and hepatic steatosis development and worsening) [49].