At the same time, the KEGG analysis indicated that the down-regulated proteins in the myocardial tissue of the SHR-PCG group were involved in multiple signal pathways related to the regulation of cardiac hypertrophy and fibrosis such as the cAMP signaling pathway, cardiomyocyte adrenergic signaling pathway, calcium signaling pathway, and Pi3k/Akt signaling pathway [7,33,34], whereas the up-regulated proteins were not found to be related to signal pathways. Here, AKT1 is linked to cardiac hypertrophy.