For example, the interaction of Ppp1cc, Pp2ca, Ryr2, and Gys1 could simultaneously participate in multiple signal transduction pathways (cAMP, cardiac adrenaline signaling pathway, and phosphatidylinositol 3-kinase-dependent pathway (Pi3k/Akt pathway), messenger RNA monitoring and insulin signaling pathways to change homeostasis and trigger a series of complex physiological and biochemical reactions eventually leading to cardiovascular disease. The gene discussed is RYR2; the disease is cardiovascular disorder.