The mechanism(s) by which chlorogenic acids exert cognitive improvements remain unclear, but Saitou et al. [7] showed an increase in serum concentration of cognitive impairment-linked biomarkers (i.e., apolipoprotein A1 (ApoA1) and Transthyretin (TTR)) levels after 16 weeks of daily chlorogenic acid supplementation. This evidence concerns the gene APOA1 and Cognitive impairment.