Our previous studies have demonstrated that DNA-hsp65 confers a high level of protection in mice both prophylactically and therapeutically [2]: it works in prevention; can be used as a BCG booster [3]; can be used alone or in association with antimycobacterial drugs to completely control chronic TB, multidrug-resistant (MDR)-TB and latent TB (LTB) infection; and can prevent reactivation of infection [4,5,6,7]. This evidence concerns the gene HSPD1 and tuberculosis.