Interestingly, IgG reactivity to PIB was similar across groups (Figure 1E); this could be due, in part, to the limited cross-reactivity of anti-porin antibodies in the sera (the majority of strains causing DGI express the PIB1A porin allele [72]) against the N. gonorrhoeae PIB1B porin that was used as the target in the ELISA assay. Here, VDAC1 is linked to dentinogenesis imperfecta.