Advanced PLWH (low CD4+T cell counts, detectable viremia, and/or previous AIDS) have weaker humoral responses to mRNA vaccines [21,25,26,27,28,29,30,31], suggesting they might benefit from additional vaccine doses in order to increase plasma antibody concentrations and subsequently achieve an optimal nAbs titer that could be effective against SARS-CoV-2 infection. Here, CD4 is linked to AIDS.