Fermented mixtures of Atractylodes macrocephala, Paeonia lactiflora, Bletilla striata, Poria cocos, Dictamnus dasycarpus, Ampelopsis japonica and Tribulus terrestris extract (FB-ChiBai) with Lactobacillus rhamnosus at concentrations ranging from 0.05% to 0.5% suppressed the CREB/MITF/tyrosinase melanogenic pathway without inducing cytotoxicity in B16F0 melanoma cells under α-MSH stimulation [20]. This evidence concerns the gene MITF and melanoma.