SETD2 and gastric cancer: Our results unequivocally indicate that IDF-11774-mediated regulation of HIF-1 α stability can potently suppress gastric cancer cell behaviors, including proliferation, migration, and invasion, by inducing cell cycle arrest and apoptosis (Figure 6) Consistent with other studies, IDF-11774 degraded HIF-1 α via the ubiquitin–proteasome system (i.e., at the post-transcriptional level rather than at the mRNA level).