Several studies revealed that IDF-11774 decreases HIF-1a levels through multiple mechanisms, not simply by increasing VHL-mediated HIF-1α degradation in colorectal cancer models in vitro and in vivo but also by inhibiting mitochondrial respiration and increasing intracellular oxygen levels [19], or acting as a heat shock protein 70 (Hsp70) inhibitor [16]. Here, VHL is linked to colorectal cancer.