In addition to altered organ function, hemodynamics, capillary permeability, acid/base disorders, endothelial injury, and enzyme activity (e.g., CYP3A), sepsis also results in changes in PK, such as increased, decreased, or unchanged drug absorption, increased distribution of hydrophilic drugs, unchanged distribution of lipophilic drugs, and altered drug clearance in the shock state [174,177,178]. The gene discussed is CYP3A4; the disease is Sepsis.