RPS6KB1 and breast carcinoma: For example, gemcitabine combined with cisplatin activates the mTOR/S6K1/NF-κB signaling pathway, up-regulates the expression of NF-κB protein and mRNA, down-regulates mTOR and S6K1 proteins, changes energy metabolism, inhibits cell proliferation, and promotes cleavage and death of breast cancer cells [30].