RuPOP interacts with NK cells, not only directly damaging tumor cells, but also triggering caspase-3 dependent cell apoptosis by upregulating NKG2D and its multiple ligands, inducing ROS production, activating various apoptosis-related receptors, such as tumor cells and tumor cells, thereby maximizing the interaction between NK cells and tumor cells. The gene discussed is CASP3; the disease is neoplasm.