CASP8 and cancer: Further in vitro studies revealed that ISL-mediated p62/sequestosome 1 (SQSTM1) induction regulated the apoptotic potential by attenuating caspase-8 activation in CRC cells, providing insights into its mechanisms of action [25], Huang et al. also reported that ISL inhibits the growth of the CRC cell line by suppressing the PI3K/Akt pathway, which is a well-established pathway known for its role in promoting cancer cell proliferation [26].