CFH and age-related macular degeneration: The most associated polymorphism to AMD is found in the CFH loci: the substitution of the histidine for tyrosine at the 42 codon of chromosome 1-region 31 (rs1061170), which results in the alteration of the sialic acid/heparin binding site in the short consensus repeat region 7 of the CFH protein [24,25,26].