In total, 103 AMD genes have been associated with AMD, but the most significantly associated are the complement factor H (CFH), age-related maculopathy susceptibility 2/high-temperature requirement A serine peptidase 1 (ARMS2/HTRA1), and apolipoprotein E (APOE) polymorphisms [23]. Here, HTRA1 is linked to age-related macular degeneration.