The key targets of Formonetin against colorectal cancer are cytochrome P450 3A4, tumor necrosis factor and cytochrome P450 1A1, and the molecular mechanism of Formonetin in the treatment of colorectal cancer may be related to the inhibition of cell proliferation and regulation of tumor-related metabolic pathways [68]. The gene discussed is CYP3A4; the disease is colorectal cancer.