MAPT and Alzheimer disease: For instance, combining α-tocopherol (an antioxidant) with donepezil (a cholinesterase inhibitor) showed promising results in an animal model of AD [6], as well as the co-delivery of BACE1 antisense sh-RNA and D-peptide, which induced both a reduction in Aβ plaque deposition and the inhibition of p-tau-related fibril formation in double transgenic (Tg) mice ((APPswe, PSEN1dE9)85Dbo/Mmjax), respectively [7].