Based on the promising findings presented in the present work, our future work will use imidazolium-supported Pd(II) 1,2 o-vanillylidene/LNPs complexes on different tumor cell lines and investigate their role on mitochondrial dynamic proteins activity and tumor progression cell cycle factors parallel with the inhibitory mechanisms for her2/neu and FGFR subunits. This evidence concerns the gene ERBB2 and neoplasm.