The synthesized encapsulated Pd(II) complexes in PdL1,2LNPs revealed significant upregulation for the levels of the expressed P53 with p < 0.05 and p < 0.001, respectively, in comparison to cisplatin activity to upregulation with p < 0.01 in comparison to the MCF-7 carcinoma cells (Figure 9A). This evidence concerns the gene TP53 and carcinoma.