Additionally, it was obvious that the lipid nanoparticles that encapsulated Pd(II) complexes triggered higher activity than the Pd(II) complexes due to their ability to penetrate the cellular membrane and maximize the activity of Pd (II) to form either covalent or non-covalent interactions with the cancer cell DNA either for FGFR2 or HER2/neu genes through the force of electrostatics between positively charged metal complexes and negatively charged DNA [56]. This evidence concerns the gene ERBB2 and cancer.