Human type 2 papillary renal cell carcinoma (PRCC2) cells were cultivated, and the results showed that accumulation of fumarate in cells lacking FH contributed to PTEN inhibition to activate PI3K/AKT signaling, tumor growth in PRCC2, and the development of sunitinib resistance in PRCC2 cells [58]. The gene discussed is FH; the disease is neoplasm.