Initially, the treatment of CF aimed to prevent or alleviate the manifestations of the disease, mainly recurrent lung infections and exocrine pancreatic failure, by means of symptomatic therapies (antibiotics, mucolytics, bronchodilators, nutritional supplements to prevent malnutrition, etc.)rather than correcting the basic defects of CFTR [20,21]. This evidence concerns the gene CFTR and cystic fibrosis.