For example, the ferroptosis inducer erastin enhances accumulation of STING in mitochondria, increasing mitochondrial fusion concomitantly with increases in ROS and lipid peroxidation, and in xenografted mice, STING KO renders these cells less prone to ferroptosis induction (in NOD/SCID mice with STING1-KD or MFN1/2-KD PANC1-derived xenograft tumor) [130]. This evidence concerns the gene STING1 and neoplasm.