It is not yet clear how normal microflora affect the cGAS-STING pathway in colorectal cancer progression, but interesting data link STING to colitis and colitis-associated cancer (CAC)—STING knock-out in mice reduces pyroptotic cell death, making the animals more prone to CAC [118] (compare this to the different results of cGAS knockout [91]). Here, CGAS is linked to colitis.