It is important to emphasize again that STING-positive cancers tend to be immunologically “hot”, while STING-negative cancers tend to be “cold”, with the clear exception of highly aggressive pancreatic ductal adenocarcinoma (PDAC) among other cold cancers, as they do not fall into the dichotomous “temperature” classification [226]. The gene discussed is STING1; the disease is pancreatic ductal adenocarcinoma.