PDCD1 and hepatocellular carcinoma: While BRCA1 functions alongside PALB2 (Partner and Localizer of BRCA2), disruption of their interaction in a hepatocellular carcinoma mouse model led to heightened T-cell infiltration and enhanced programmed cell death protein 1 (PD-1) antibody response, in sync with both intrinsic and extrinsic cGAS-STING activation [114].