NFKB1 and cancer: Certain cancers, like breast and lung cancers, grow with induced cGAS-STING and simultaneous activation of the non-canonical NF-κB pathway, where the chain of events such as tumor necrosis factor receptor (TNFR)-dependent chronic activation of NF-κB-inducing kinase (NIK), followed by NIK-mediated p100 phosphorylation, p100 processing, and nuclear translocation of p52 and RELB, leads to changes in genes expression.