Garlic extract, which contains various phytochemicals such as allicin, alliin, diallyl disulfate, diallyl trisulfide, ajoene, and s-allyl cystine, was shown to increase the ratio of CD4+/CD8+, enhance the production of IFN-γ in splenocyte of fibroblast tumors, and increase IFN- γ, IL-2, IL-4 levels in breast cancer in Wistar rats [161]. This evidence concerns the gene CD8A and breast cancer.