In this sense, the data obtained reinforce the potential and safety of Lu entrapped in NLC and effectively demonstrate the in vivo leishmanicidal action of Lu in this nanosystem, indicating that this triterpene can be considered an interesting molecule in the search for potential leishmanicidal agents and, when formulated in NLC, has its therapeutic activities potentialized through the targeted distribution of the drug to target organs of parasites, being a potential therapeutic alternative in the treatment of visceral leishmaniasis. Here, BCAM is linked to visceral leishmaniasis.