Genetic inactivation of core genes within this tumor-suppressor kinase cascade (for example, about 35% to 40% of malignant pleural mesotheliomas cases carry an inactivating mutations at the neurofibromatosis 2, NF2, locus) or genetic amplification of YAP/TAZ transcriptional regulator (for example, more than 15% of cervical squamous cell carcinoma are driven by YAP/TAZ amplification) converge on TEAD transcription factors to establish an oncogenic transcriptional program that promotes uncontrolled cell proliferation [6,10]. The gene discussed is NF2; the disease is cervical squamous cell carcinoma.