In about 30–40% of malignant pleural mesothelioma cases, for example, the NF2 (Neurofibromatosis type 2) tumor suppressor gene is somatically inactivated, leading to defective recruitment of LATS1/2 kinases to the plasma membrane and impaired Hippo signaling [9,10]. Here, NF2 is linked to malignant pleural mesothelioma.